Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.
The Gallaghers adjust to life during the pandemic. Frank fears gentrification of South Side. Bar closures force Kev and V to get creative. Lip and Tami work to make their new house a home as Carl finishes his time at the police academy.
Frank helps Kev and V's pot business. Debbie prepares a princess party for Franny while Mickey gets a real job. Lip runs into trouble with his new neighbors. Carl's first day on the force is not what he thought it would be.
Debbie loses track of Franny, while Frank and Franny have a day of weed runs and adventure. Ian and Mickey question who is the "man" in their relationship. Carl gets a new training officer. Lip and Tami help Brad and Cami with their baby.
The Milkoviches move in next door and wreak havoc, leading Frank, Kev and Liam to scheme to get rid of them. Mickey embarks on a security gig for Kev and V and drags Ian along. Gemma and Franny compete in the Little Miss South Side beauty pageant.
Ian and Mickey get creative when the safety of their security gig comes into question. Dynamic duo Frank and Kev make a last-ditch effort to take down the Milkovich’s. V canvasses to get black people to the polls but realizes there’s barely any black people left on the Southside.
A surprising twist of fate has left the Milkovich’s vulnerable, forcing Ian and Mickey to step in to help. Frank’s day takes some unexpected turns and Liam deals with inner turmoil after doing a bad thing. Debbie confronts Sandy on their relationship, while Carl enjoys the spoils of his day off.
The Gallaghers disagree on the fate of their childhood home so a stranded Frank tries to get back to weigh in on the matter. Realizing that they have none, Ian and Mickey embark on a journey to find gay friends. Carl is upset after his night with Tish, and Debbie and Sandy have another visitor from Sandy’s past.
Frank and Liam compete in a renaming contest of the Dennis Hastert Middle School. Debbie has a day of zero responsibilities, while Ian and Mickey take on all the responsibility for Terry. Veronica is depressed about her mom moving so Kevin tries to cheer her up, all while planning a special surprise.
Frank wants to pull one last heist with the old gang. Debbie struggles with the idea of change and blames Lip, while Lip and Brad find out the new owners of BornFree are in the mob. Mickey and Ian learn a surprising truth about Terry’s past, and Liam tries to find a new place to live.
Lip has a million projects going on, and Frank is one of them. Liam is forced to watch Frank, so the two of them embark on a journey to take down Liam’s classmate in an effort to get Liam into STEM school. Carl’s disillusionment with the police force comes to a head.
Kev and V announce their big news. Lip has some promising leads on selling the house, forcing Debbie to reevaluate her future and her history of regrettable love interests. Ian and Mickey try to adjust to a vastly different life on the West Side. Carl’s commitment to the force is challenged when he’s reassigned to an unglamorous police unit. Liam reminds Frank of everything that makes Frank, Frank.
Ian and Mickey shop for furniture for their new place and Kev and V look for a buyer for the Alibi. While Lip settles for a new job, Carl finally finds his calling in a new role on the police force. Debbie plunges into a treacherous world when she meets someone new. Frank comes to terms with his own mortality.